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Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice.

Mohammed A A SalehBerfin GülaveOlivia CampagneClinton F StewartJeroen Elassaiss-SchaapElizabeth C M De Lange
Published in: Pharmaceutical research (2023)
from healthy mice for most drugs. This brings the translation between mouse and human brain PK one step further.
Keyphrases
  • high fat diet induced
  • white matter
  • resting state
  • wild type
  • metabolic syndrome
  • functional connectivity
  • multiple sclerosis
  • brain injury
  • subarachnoid hemorrhage
  • drug induced