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MAIT cells ameliorate liver fibrosis by enhancing the cytotoxicity of NK cells in cholestatic murine models.

Xiang JiangYanan PengLan LiuYouwei WangMengting LiWenjie LiFengxing HuangChunlan ZhengFei XuQian HuWanhui WeiShouquan DongZhao Qiu
Published in: Liver international : official journal of the International Association for the Study of the Liver (2022)
Our findings indicate that MAIT cells ameliorate cholestatic liver fibrosis by enhancing the cytotoxicity of NK cells against HSCs. An in-depth understanding of the MAIT cell-mediated regulatory effect will provide more valuable immunotherapy strategies to treat liver fibrosis.
Keyphrases
  • liver fibrosis
  • nk cells
  • induced apoptosis
  • cell cycle arrest
  • endoplasmic reticulum stress
  • single cell
  • stem cells
  • oxidative stress
  • cell death
  • signaling pathway
  • cell therapy
  • bone marrow
  • liver injury
  • drug induced