Cell-free DNA comparative analysis of the genomic landscape of first-line hormone receptor-positive metastatic breast cancer from the US and China.
Xiaoran LiuAndrew A DavisFeng XieXinyu GuiYifei ChenQiang ZhangLorenzo GerratanaYoubin ZhangAmi N ShahAmir BehdadFiras WehbeYong HuangJianjun YuPan DuShidong JiaHuiping LiMassimo CristofanilliPublished in: Breast cancer research and treatment (2021)
The differential prevalence of ctDNA-based alterations such as FGFR1, AKT1, and CDH1 was observed in initially HR+/HER2- MBC patients in the US vs. CN. In addition, the association of PTEN deletions with shorter PFS was found in the CN but not the US cohort. The differential genomic landscapes across the two ethnic groups may reflect biologic differences and clinical implications.
Keyphrases
- metastatic breast cancer
- end stage renal disease
- cell proliferation
- ejection fraction
- chronic kidney disease
- newly diagnosed
- lymph node metastasis
- rheumatoid arthritis
- copy number
- risk factors
- prognostic factors
- peritoneal dialysis
- squamous cell carcinoma
- patient reported outcomes
- pi k akt
- dna methylation
- genome wide
- patient reported
- circulating tumor