Spatially Resolved Tumor Microenvironment Predicts Treatment Outcomes in Relapsed/Refractory Hodgkin Lymphoma.

Tomohiro Aoki Aixiang Jiang Alexander M XuYifan YinAlicia Gamboa Katy MilneKatsuyoshi TakataTomoko Miyata-TakataShanee Chung Shinya RaiShaocheng WuMary E Warren Celia StrongTalia GoodyearKayleigh MorrisLauren C ChongMonirath HavAnthony R ColomboAdele TeleniusMerrill BoyleSusana Ben-NeriahMaryse PowerAlina S GerrieAndrew P WengAly Karsan Andrew J Roth Pedro Farinha David W Scott Kerry Joane Savage Brad H Nelson Akil A Merchant Christian Steidl

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)

We identified the interaction of CXCR5+ HRS cells with ligand-expressing CXCL13+ macrophages as a prominent crosstalk axis in relapsed CHL. Harnessing this TME biology, we developed a novel prognostic model applicable to r/r CHL biopsies, RHL4S, opening new avenues for spatial biomarker development.

Keyphrases

hodgkin lymphoma
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
cell migration
signaling pathway
cell proliferation