TIM-1 serves as a receptor for Ebola virus in vivo, enhancing viremia and pathogenesis.
Bethany BruntonKai RogersElisabeth K PhillipsRachel B BrouilletteRuayda BoulsNoah S ButlerWendy J MauryPublished in: PLoS neglected tropical diseases (2019)
Our studies provide evidence that at late times during EBOV GP/rVSV infection, TIM-1 increased virus load and associated mortality, consistent with an important role of this receptor in virus entry. This work suggests that inhibitors which block TIM-1/virus interaction may serve as effective antivirals, reducing virus load at late times during EBOV infection.