Icos gene disruption in non-obese diabetic mice elicits myositis associated with anti-troponin T3 autoantibodies.
Gwladys BourdenetBaptiste PileyreLaurent DrouotJérémie MartinetChantal BécourtMarion CarretteGaétan RiouCécile BerguaThara JaworskiPhilippe ChanLaetitia JeanManuel FréretPascal CosetteChristian BoitardCatalina AbadOlivier BoyerPublished in: Neuropathology and applied neurobiology (2023)
NOD mice represent a spontaneous model of myositis and the discovery of anti-TNNT3 aAb suggests a new autoantigen in this model.
Keyphrases
- interstitial lung disease
- adipose tissue
- metabolic syndrome
- type diabetes
- small molecule
- systemic lupus erythematosus
- high throughput
- genome wide
- myasthenia gravis
- copy number
- dna methylation
- gene expression
- high fat diet induced
- transcription factor
- obese patients
- insulin resistance
- idiopathic pulmonary fibrosis
- single cell
- genome wide identification