Associations between atypical intracortical myelin content and neuropsychological functions in middle to older aged adults with ASD.
Jiwandeep S KohliAnnika C LinkeIan A MartindaleMolly WilkinsonMikaela K KinnearAlan J LincolnJanice HauIan ShryockVinton OmalekiKalekirstos AlemuStephanie PedrahitaInna FishmanRalph-Axel MüllerRuth A CarperPublished in: Brain and behavior (2024)
The group-level and subject-level approaches employed here demonstrate the value of examining inter-individual variability and provide important preliminary insights into relationships between brain structure and cognition in the second half of the lifespan in ASD, suggesting shared factors contributing to atypical intracortical myelin content and poorer cognitive outcomes for a subset of middle aged to older autistic adults. These atypicalities likely reflect diverse histories of neurodevelopmental deficits, and possible compensatory changes, compounded by processes of aging, and may serve as useful markers of vulnerability to further cognitive decline in older adults with ASD.
Keyphrases
- middle aged
- cognitive decline
- mild cognitive impairment
- autism spectrum disorder
- white matter
- community dwelling
- attention deficit hyperactivity disorder
- intellectual disability
- physical activity
- traumatic brain injury
- multiple sclerosis
- brain injury
- metabolic syndrome
- subarachnoid hemorrhage
- insulin resistance
- finite element
- glycemic control