RNA-seq reveals downregulated osteochondral genes potentially related to tibia bacterial chondronecrosis with osteomyelitis in broilers.

Haniel Cedraz de OliveiraAdriana Mércia Guaratini IbelliSimone Eliza Facioni GuimarãesMauricio Egídio CantãoJane de Oliveira PeixotoLuiz Lehmann CoutinhoMônica Corrêa Ledur

Published in: BMC genetics (2020)

Our data show that osteochondral downregulated genes are potential molecular causes of BCO in broilers, and the bacterial process seems to be, in fact, a secondary condition. Sixteen genes responsible for bone and cartilage formation were downregulated in BCO-affected broilers being strong candidate genes to trigger this disorder.

Keyphrases

rna seq
genome wide
heat stress
single cell
bioinformatics analysis
genome wide identification
electronic health record
dna methylation
machine learning
risk assessment
deep learning
extracellular matrix
soft tissue
human health