Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression.
Carolina F RuivoNuno BastosBarbara AdemInes BatistaCecilia DuraesCarlos A MeloStephanie A CastaldoFrancisco Campos-LaboriePedro Moutinho-RibeiroBarbara MorãoAna Costa-PintoSoraia SilvaHugo OsorioSergio CiordiaJose Luis CostaDavid GoodrichBruno CavadasLuisa PereiraTony KouzaridesGuilherme MacedoRui MaioFatima CarneiroMarília CravoRaghu KalluriJosé Carlos MachadoSonia A MeloPublished in: Gut (2022)
PDAC tumours establish a cooperation network mediated by EVs that is led by CSC and agrin, which allows tumours to adapt and thrive. Targeting agrin could make targeted therapy possible for patients with PDAC and has a significant impact on CSC that feeds the tumour and is at the centre of therapy resistance.