In Vivo Simvastatin and Brain Radiation in a Model of HER2 + Inflammatory Breast Cancer Brain Metastasis.
Swaminathan KumarRichard A LarsonShane R SteckleinJay P ReddyBisrat G DebebRichard A AmosStephanie M ColognaWendy A WoodwardPublished in: bioRxiv : the preprint server for biology (2024)
Although a role for cholesterol biosynthesis is demonstrated in DNA repair and response to whole brain radiation in this model, durable in vivo efficacy of concurrent whole brain irradiation and oral statin was not demonstrated.