MiRNAs expression profiling of rat ovaries displaying PCOS with insulin resistance.

Chunren ZhangChuyi YuZengxian LinHaixia PanKunyin LiHong-Xia Ma

Published in: Archives of gynecology and obstetrics (2020)

These results indicate that differentially expressed miRNAs in rat ovaries may be involved in the pathophysiology of insulin resistance in PCOS. Our study may be beneficial in establishing miRNAs as novel diagnostic and therapeutic biomarkers for insulin resistance in PCOS.

Keyphrases

polycystic ovary syndrome
insulin resistance
oxidative stress
adipose tissue
metabolic syndrome
type diabetes
high fat diet
skeletal muscle
genome wide
high fat diet induced