Sulforaphane Does Not Protect Right Ventricular Systolic and Diastolic Functions in Nrf2 Knockout Pulmonary Artery Hypertension Mice.

Guangyan ZhangYin KangDakotah CatheyAmanda J LeBlancJun CaiLu CaiSheng WangJiapeng HuangBradley B Keller

Published in: Cardiovascular drugs and therapy (2022)

Our findings demonstrated the essential role of Nrf2 in SFN-mediated prevention of RV dysfunction and PAH, and increasing Nrf2 activity in patients with PAH may have therapeutic potential.

Keyphrases

pulmonary artery
oxidative stress
blood pressure
coronary artery
pulmonary hypertension
left ventricular
pulmonary arterial hypertension
mycobacterium tuberculosis
heart failure
polycyclic aromatic hydrocarbons
metabolic syndrome
adipose tissue
insulin resistance