Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines.
Minori TamaiMeixian HuangKeiko KagamiMasako AbeShinpei SomazuTamao ShinoharaDaisuke HaramaAtsushi WatanabeKoshi AkahaneKumiko GoiKanji SugitaHiroaki GotoMasayoshi MinegishiShotaro IwamotoTakeshi InukaiPublished in: Cancer cell international (2020)
These observations in 72 BCP-ALL cell lines suggested that the risk allele of the relapse-linked SNPs of ARID5B may be involved in a higher relapse rate because of resistance to chemotherapeutic agents such as VCR, CY, and AraC. In addition, lower ARID5B gene expression may be associated with MTX resistance.