The Neuropilin-1/PKC axis promotes neuroendocrine differentiation and drug resistance of prostate cancer.

Charly BlancAnissa MoktefiAriane JollyPierre de la GrangeDenise GayNathalie NicolaiewFannie SemprezPascale MailléPascale SoyeuxVirginie FirlejFrancis VacherotDamien DestouchesMohamed AmicheStéphane TerryAlexandre de la TailleJosé-Arturo Londono-VallejoYves AlloryJean DelbéYamina Hamma-Kourbali

Published in: British journal of cancer (2022)

This study reveals the NRP1/PKC axis as a promising therapeutic target for the prevention of neuroendocrine castration-resistant variants of PCa and indicates NRP1 as an early transitional biomarker.

Keyphrases

prostate cancer
radical prostatectomy
protein kinase
gene expression
genome wide