A novel adjustable automated system for inducing chronic intermittent hypoxia in mice.
Dora PolšekMarcel BagoMarija ŽivaljićIvana RosenzweigZsombor LaczaSrećko GajovićPublished in: PloS one (2017)
The new design of a hypoxic chamber provides a fast, adjustable and reliable model of obstructive sleep apnea, which was validated by apoptosis of hippocampal neurons.
Keyphrases
- obstructive sleep apnea
- oxidative stress
- endoplasmic reticulum stress
- positive airway pressure
- cell cycle arrest
- high fat diet induced
- machine learning
- spinal cord
- deep learning
- high throughput
- endothelial cells
- high intensity
- sleep apnea
- drug induced
- insulin resistance
- pi k akt
- cell proliferation
- blood brain barrier