Metabolic response of glioblastoma cells associated with glucose withdrawal and pyruvate substitution as revealed by GC-MS.

Henry OppermannYonghong DingJeevan SharmaMandy Berndt PaetzJürgen MeixensbergerFrank GaunitzClaudia Birkemeyer

Published in: Nutrition & metabolism (2016)

Our experiments reveal a high plasticity of glioblastoma cells to changes in nutritional supply which has to be taken into account in clinical trials in which specific diets are considered for therapy.

Keyphrases

induced apoptosis
clinical trial
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
gene expression
stem cells
cell death
type diabetes
signaling pathway
adipose tissue
blood glucose
dna methylation
blood pressure
mesenchymal stem cells
double blind
placebo controlled