Association of olfaction dysfunction with brain microstructure in prodromal Parkinson disease.
Hossein Sanjari MoghaddamMahsa DolatshahiElaheh SalardiniMohammad Hadi AarabiPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2018)
These results indicate that PD and prodromal PD patients, which were matched for sex, UPSIT, and MoCA scores, have different white matter fiber architecture. Thus, it is postulated that olfaction dysfunction in prodromal and early clinical phases of PD may involve distinct pathogenesis. Increased network connectivity in prodromal and early PD may suggest the neural compensation.