Real-world outcomes in patients with metastatic renal cell carcinoma according to risk factors: the STAR-TOR registry.
Arne StraussMarianne SchmidMichael RinkMichael MoranStephan BernhardtMarcus HubbeLothar BergmannKatrin SchlackMartin BoegemannPublished in: Future oncology (London, England) (2021)
Aim: Examine outcomes in sunitinib-treated patients by International Metastatic RCC Database Consortium (IMDC) or Memorial Sloan-Kettering Cancer Center (MSKCC) risk factors. Patients & methods: Patients enrolled in STAR-TOR registry (n = 327). End points included overall survival, progression-free survival and objective response rate. Results: Overall survival was similar for IMDC 0 versus 1 (p = 0.238) or 2 versus ≥3 (p = 0.156), but different for MSKCC (0 vs 1, p = 0.037; 2 vs ≥3, p = 0.001). Progression-free survival was similar for IMDC 2 versus 3 (p = 0.306), but different for MSKCC (p = 0.009). Objective response rate was different for IMDC 1 (41.9%) and 2 (29.5%) and similar for MSKCC 1 (34.4%) and 2 (31.0%). Conclusion: Outcome data varied according to IMDC or MSKCC. MSKCC model accurately stratify patients into risk groups. Clinical trial registration: NCT00700258 (ClinicalTrials.gov).
Keyphrases
- end stage renal disease
- free survival
- newly diagnosed
- ejection fraction
- risk factors
- clinical trial
- chronic kidney disease
- peritoneal dialysis
- type diabetes
- emergency department
- squamous cell carcinoma
- small cell lung cancer
- patient reported outcomes
- machine learning
- metastatic renal cell carcinoma
- study protocol
- electronic health record
- patient reported
- drug induced
- phase iii