Antitubercular and Cytotoxic Chlorinated seco-Cyclohexenes from Uvaria alba.

Allan Patrick G MacabeoArianne G LetadaSimon BuddeChristian FaderlHans-Martin DahseScott G FranzblauGrecebio Jonathan D AlejandroGregory K PierensMary J Garson

Published in: Journal of natural products (2017)

Two new chlorine-containing polyoxygenated seco-cyclohexenes, albanols A (1) and B (2), along with the oxepinone metabolite grandiuvarone (3) were isolated from the endemic Philippine Annonaceae plant Uvaria alba. Both new compounds exhibited modest antitubercular activity. Compound 1 showed cytostatic activity (ranging from 1-50 μM) against HeLa cells and weak antiproliferative activity against HUVEC and K-562 cells with GI50 values of 106 and 81 μM, respectively.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
drinking water
mass spectrometry
polycyclic aromatic hydrocarbons
gas chromatography