Altered crosstalk of estradiol and progesterone with Myeloid-derived suppressor cells and Th1/Th2 cytokines in early miscarriage is associated with early breakdown of maternal-fetal tolerance.

Priyanka VermaRachna VermaRohini R NairSnehil BudhwarAnuradha KhannaNisha Rani AgrawalRuchi SinhaRuchi BirendraSingh RajenderKiran Singh

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2019)

Altogether, this unfavorable systemic milieu may drive toward early breakdown of maternal-fetal tolerance in EM. Therefore, regulated crosstalk of E2, P4 with MDSCs and balanced Th1/Th2 cytokines is prerequisite for successful pregnancy.

Keyphrases

pregnancy outcomes
birth weight
estrogen receptor
preterm birth
body mass index
pregnant women
physical activity
cell proliferation
gestational age
endoplasmic reticulum stress