Absence of TFE3 Immunoexpression in a Spectrum of Cutaneous Mixed Tumors: A Retrospective Pilot Study.

Hatice B ZenginBahadir YildizTatsiana PukhalskayaBruce R Smoller

Published in: Dermatopathology (Basel, Switzerland) (2022)

Our study failed to reveal possible TFE3 gene fusion by IHC staining in benign, atypical, and malignant chondroid syringomas. Although the negative staining in MCS suggests a genetic heterogeneity in this entity, further studies with larger case groups are needed for a more definitive conclusion.

Keyphrases

genome wide
single cell
copy number
flow cytometry
dna methylation
locally advanced
case control
radiation therapy