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Pharmacokinetics and pharmacodynamics of an oral formulation of decitabine and tetrahydrouridine.

Henry LauPhilip G WoostUte FriedrichWan Hui Ong ClausenJames W JacobbergerYogen Saunthararajah
Published in: European journal of haematology (2023)
Combination oral formulations of THU with decitabine produced pharmacokinetics and pharmacodynamics suitable for oral DNMT1-targeted therapy.
Keyphrases
  • acute myeloid leukemia
  • dna methylation
  • gene expression