NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport.

Sen YangZhen-Xian NiouAndrea EnriquezJacob LaMarJui-Yen HuangKaren LingPaymaan Jafar-NejadJonathan GilleyMichael P ColemanJason M TennessenVidhya RangarajuHui-Chen Lu

Published in: Molecular neurodegeneration (2024)

NMNAT2 ensures axonal health by maintaining NAD redox potential in distal axons to ensure efficient vesicular glycolysis required for fast axonal transport.

Keyphrases

spinal cord injury
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peripheral nerve