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Application of network pharmacology and molecular docking approach to explore active compounds and potential pharmacological mechanisms of Aconiti Lateralis Radix Praeparata and Lepidii Semen Descurainiae Semen for treatment of heart failure.

Meng-Qi YangCong ChenYi-Fei MaoYan LiXia ZhongYi-Ding YuYi-Tao XueYong-Mei Song
Published in: Medicine (2022)
Based on the combined approach of network pharmacology and molecular docking, this study screened out the main active compounds, key targets, and main pathways of ALRP-LSDS for the treatment of HF, and revealed its potential mechanisms, providing a theoretical basis for further research.
Keyphrases
  • molecular docking
  • heart failure
  • molecular dynamics simulations
  • left ventricular
  • risk assessment
  • combination therapy
  • climate change