Advanced Magnetic Resonance Imaging to Define the Microvascular Injury Driven by Neuroinflammation in the Brain of a Mouse Model of Hypertension.
Lorenzo CarnevaleMarialuisa PerrottaFrancesco MastroiacovoSara PerrottaAgnese MigliaccioValentina FardellaJacopo PacellaStefania FardellaFabio PallanteRaimondo CarnevaleDaniela CarnevaleGiuseppe LemboPublished in: Hypertension (Dallas, Tex. : 1979) (2024)
Overall, we have used translational tools to comprehensively characterize brain injury in a mouse model of hypertension induced by chronic pressure overload. We have identified early cerebrovascular damage in hypertensive mice, sustained by CD8+IFN-γ+T lymphocytes, which fuel neuroinflammation to establish the injury of brain capillaries.
Keyphrases
- cerebral ischemia
- brain injury
- mouse model
- blood pressure
- subarachnoid hemorrhage
- magnetic resonance imaging
- resting state
- blood brain barrier
- white matter
- traumatic brain injury
- lipopolysaccharide induced
- lps induced
- dendritic cells
- immune response
- functional connectivity
- computed tomography
- cognitive impairment
- oxidative stress
- high fat diet induced
- type diabetes
- inflammatory response
- multiple sclerosis
- contrast enhanced
- wild type