Heterogeneity of contemporary grade group 4 prostate cancer in radical prostatectomy specimens.
Alberto MartiniAlae TouzaniJean-Baptiste BeauvalAlain RuffionJonathan OlivierAnis GasmiCharles DarianeMatthieu ThoulouzanEric BarretLaurent BrureauGilles CréhangeGaëlle FiardMathieu GauthéRaphaële Renard-PennaGuilhem RoubaudPaul SargosMathieu RoumiguiéMarc-Olivier TimsitRomain MathieuArnauld VillersMorgan RouprêtGaëlle FromontGuillaume Ploussardnull nullPublished in: World journal of urology (2022)
Patients with tumor grade 3 + 5 had better pathological and prognostic outcomes compared to 4 + 4 or 5 + 3. When accounting for tumor architecture, the sub-stratification into subgroups lost its prognostic role and tumor architecture was the sole predictor of poorer prognosis in terms of biochemical recurrence.