Microglial VPS35 deficiency regulates microglial polarization and decreases ischemic stroke-induced damage in the cortex.
Shi-Yang YeJoanna E AppleXiao RenFu-Lei TangLing-Ling YaoYong-Gang WangLin MeiYuan-Guo ZhouWen-Cheng XiongPublished in: Journal of neuroinflammation (2019)
Together, these results reveal an unrecognized function of microglial VPS35 in enhancing ischemic brain injury-induced inflammatory microglia, but suppressing the injury-induced anti-inflammatory microglia. Consequently, microglial VPS35 cKO mice exhibit attenuation of ischemic brain injury response.
Keyphrases
- endothelial cells
- high glucose
- brain injury
- inflammatory response
- subarachnoid hemorrhage
- neuropathic pain
- cerebral ischemia
- lipopolysaccharide induced
- lps induced
- oxidative stress
- diabetic rats
- anti inflammatory
- drug induced
- spinal cord injury
- atrial fibrillation
- ischemia reperfusion injury
- gene expression
- genome wide
- single cell
- functional connectivity
- stress induced