Proteoglycan synthesis rate as a novel method to measure blood-induced cartilage degeneration in non-haemophilic and haemophilic rats.
Astrid E PullesKåre Kryger VølsKristine R ChristensenKatja CoeleveldAxel K HansenLize F D van VulpenMaj PetersenSimon C MastbergenKirstine RoepstorffRoger E G SchutgensMads Kjelgaard-HansenFloris P J G LafeberPublished in: Haemophilia : the official journal of the World Federation of Hemophilia (2020)
For the first time, early changes in cartilage matrix synthesis upon blood exposure were quantified with the 35 SO4 2- assay in a haemophilic rat model, establishing this assay as a novel method to study blood-induced cartilage damage.