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Oxygen Tolerant and Cytocompatible Iron(0)-Mediated ATRP Enables the Controlled Growth of Polymer Brushes from Mammalian Cell Cultures.

Amine LayadiBenjamin KesselWenqing YanMatteo RomioNicholas D SpencerMarcy Zenobi-WongKrzysztof MatyjaszewskiEdmondo M Benetti
Published in: Journal of the American Chemical Society (2020)
The use of zerovalent iron (Fe0)-coated plates, which act both as a source of catalyst and as a reducing agent during surface-initiated atom transfer radical polymerization (SI-ATRP), enables the controlled growth of a wide range of polymer brushes under ambient conditions utilizing either organic or aqueous reaction media. Thanks to its cytocompatibility, Fe0 SI-ATRP can be applied within cell cultures, providing a tool that can broadly and dynamically modify the substrate's affinity toward cells, without influencing their viability. Upon systematically assessing the application of Fe-based catalytic systems in the controlled grafting of polymers, Fe0 SI-ATRP emerges as an extremely versatile technique that could be applied to tune the physicochemical properties of a cell's microenvironments on biomaterials or within tissue engineering constructs.
Keyphrases
  • tissue engineering
  • single cell
  • cell therapy
  • room temperature
  • metal organic framework
  • induced apoptosis
  • ionic liquid
  • cell death
  • cell cycle arrest
  • particulate matter
  • cell proliferation
  • reduced graphene oxide