Risk of upper gastrointestinal bleeding in patients on oral anticoagulant and proton pump inhibitor co-therapy.
Hyun-Jung LeeHyung Kwan KimBongseong KimKyung-Do HanJun-Bean ParkHeesun LeeSeung-Pyo LeeYong-Jin KimPublished in: PloS one (2021)
In patients on oral anticoagulant and PPI co-therapy, NOACs were associated with lower risk of upper gastrointestinal bleeding and mortality compared to warfarin, while there was no difference among the oral anticoagulants for stroke prevention. In patients on PPI therapy, NOACs may preferred over warfarin for decreasing risk of upper gastrointestinal bleeding and mortality.
Keyphrases
- atrial fibrillation
- oral anticoagulants
- end stage renal disease
- venous thromboembolism
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- stem cells
- cardiovascular events
- cardiovascular disease
- risk factors
- small molecule
- coronary artery disease
- mesenchymal stem cells
- brain injury
- blood brain barrier
- protein protein
- patient reported