Selected ginsenosides of the protopanaxdiol series are novel positive allosteric modulators of P2X7 receptors.

R M HelliwellC O ShioukHueyK DhunaJ C MoleroJ-M YeC C XueLeanne Stokes

Published in: British journal of pharmacology (2015)

This study identifies selected ginsenosides as novel potent allosteric modulators of P2X7 channels that may account for some of the reported immune modulatory actions of protopanaxdiol ginsenosides in vivo.

Keyphrases

small molecule
gene expression
dna methylation