Inhibition of miRNA-1-Mediated Inflammation and Autophagy by Astragaloside IV Improves Lipopolysaccharide-Induced Cardiac Dysfunction in Rats.

Qiuning WangWeiying ChenXuefeng YangYing SongXiaowei SunGuizhou TaoHong WangNan ZhaoYue HuangErqing ChaiFu-Tian Tang

Published in: Journal of inflammation research (2022)

These results suggest that AS-IV attenuated cardiac dysfunction caused by LPS by inhibiting miR-1-mediated inflammation and autophagy, thereby providing a novel mechanism for the protection against cardiac diseases.

Keyphrases

oxidative stress
lipopolysaccharide induced
inflammatory response
left ventricular
signaling pathway
cell death
endoplasmic reticulum stress
cell proliferation
heart failure
anti inflammatory