Patient-Derived Xenograft Engraftment and Breast Cancer Outcomes in a Prospective Neoadjuvant Study (BEAUTY).
Judy C BougheyVera J SumanJia YuKatelyn SantoJason P SinnwellJodi M CarterKrishna R KalariXiaojia TangSarah A McLaughlinAlvaro Moreno-AspitiaDonald W NorthfeltRichard J GrayKatie N HuntAmy Lynn ConnersJames N IngleAnn M MoyerRichard WeinshilboumJohn A CoplandLiewei WangMatthew P GoetzPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
In treatment-naïve breast cancer receiving standard NAC, PDX engraftment was not prognostic for breast cancer recurrence. Further study is needed to establish whether PDX engraftment in the treatment-resistant setting is prognostic for cancer recurrence.