Aging leads to dysfunctional innate immune responses to TLR2 and TLR4 agonists.
Kristina L BaileyLynette M SmithArt J HeiresDawn M KatafiaszDebra J RombergerTricia D LeVanPublished in: Aging clinical and experimental research (2018)
With aging, circulating leukocytes produce high levels of TNFα at baseline and have inadequate responses to TLR2 and TLR4 agonists. These defects likely contribute to the increased susceptibility to sepsis in older adults.