High-resolution plasma metabolomics analysis to detect Mycobacterium tuberculosis-associated metabolites that distinguish active pulmonary tuberculosis in humans.

Jeffrey M CollinsDouglas I WalkerDean P JonesNestani TukvadzeKen H LiuViLinh T TranKaran UppalJennifer K FredianiKirk A EasleyNeeta ShenviManoj KhadkaEric A OrtlundRussell R KempkerHenry M BlumbergThomas R Ziegler

Published in: PloS one (2018)

Presence of the Mtb-associated lipid metabolites PG (16:0_18:1) and Lyso-PI (18:0) in plasma accurately identified patients with active TB disease. Consistency of in vitro and in vivo data suggests suitability for exploring these in future studies for possible development as TB disease biomarkers.

Keyphrases

mycobacterium tuberculosis
pulmonary tuberculosis
high resolution
ms ms
mass spectrometry
electronic health record
current status
machine learning
big data
artificial intelligence
case control
data analysis