Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration.

Dibyadeep DattaIsabella PeroneDenethi WijegunawardanaFeng LiangYury M MorozovJon ArellanoAlvaro DuqueZhongcong XieChristopher H van DyckMary Kate P JoyceAmy F T Arnsten

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

These data help to explain why pT217-tau predicts degeneration in AD and how it gains access to CSF and plasma to serve as a fluid biomarker.

Keyphrases

prefrontal cortex
early stage
cerebrospinal fluid
high resolution
electronic health record
big data
atomic force microscopy
sentinel lymph node
fluorescence imaging
machine learning
data analysis
radiation therapy
squamous cell carcinoma
neoadjuvant chemotherapy