Activation of AMP-activated protein kinase by metformin ablates angiotensin II-induced endoplasmic reticulum stress and hypertension in mice in vivo.
Quanlu DuanMing-Hui ZouYe DingMing-Hui ZouPublished in: British journal of pharmacology (2017)
Metformin alleviates Ang II-triggered hypertension in mice by activating AMPKα2, which mediates phospholamban phosphorylation and inhibits Ang II-induced ER stress in vascular smooth muscle cells.
Keyphrases
- angiotensin ii
- vascular smooth muscle cells
- protein kinase
- endoplasmic reticulum stress
- angiotensin converting enzyme
- blood pressure
- high glucose
- induced apoptosis
- diabetic rats
- high fat diet induced
- signaling pathway
- drug induced
- skeletal muscle
- type diabetes
- endothelial cells
- wild type
- adipose tissue
- insulin resistance
- arterial hypertension
- stress induced