HBV transcription and translation persist despite viral suppression in HBV-HIV co-infected patients on antiretroviral therapy.
Mauricio Lisker-MelmanAbdus S WahedMarc G GhanyRaymond T ChungWendy C KingDavid E KleinerAtul K BhanMandana KhaliliMamta K JainMark S SulkowskiDavid K WongGavin ClohertyRichard K SterlingPublished in: Hepatology (Baltimore, Md.) (2022)
HBcAg and HBsAg IHC staining persisted despite viral suppression, and IHC grades and staining patterns correlated with markers of transcription (HBV RNA) and translation (HBcrAg). These data indicate that apparent HBV suppression is associated with residual transcription and translation that could contribute to liver pathology. Additional antiviral strategies directed to HBV protein expression may be useful to ameliorate liver injury.
Keyphrases
- hepatitis b virus
- antiretroviral therapy
- liver failure
- liver injury
- hiv infected
- drug induced
- hiv positive
- human immunodeficiency virus
- transcription factor
- sars cov
- hiv aids
- hiv infected patients
- hepatitis c virus
- magnetic resonance
- machine learning
- electronic health record
- big data
- computed tomography
- artificial intelligence
- hiv testing
- men who have sex with men
- data analysis