Prevalence, characteristics and outcomes of older patients with hereditary versus wild-type transthyretin amyloid cardiomyopathy.

Aldostefano Porcari Yousuf Razvi Ambra MasiRishi PatelAdam IoannouMuhammad U RaufDavid F HuttDorota RowczenioJanet GilbertsonAna Martinez-NaharroLucia VenneriCarol WhelanHelen LachmannAshutosh WechalekarCandida Cristina QuartaMarco MerloGianfranco SinagraPhilip N HawkinsMarianna FontanaJulian D Gillmore

Published in: European journal of heart failure (2023)

Up to 20.7% of elderly patients with ATTR-CM have a pathogenic TTR variant. These findings support routine sequencing of the TTR gene in all patients with ATTR-CM regardless of age.

Keyphrases

wild type
risk factors
heart failure
clinical practice
single cell
copy number
genome wide
dna methylation
transcription factor