Investigating the relationship between depression and breast cancer: observational and genetic analyses.

Xueyao WuWenqiang ZhangXunying ZhaoLi ZhangMinghan XuYu HaoJinyu XiaoBen ZhangJiayuan LiPeter KraftJordan W SmollerXia Jiang

Published in: BMC medicine (2023)

Our work demonstrates a shared genetic basis, pleiotropic loci, and a putative causal relationship between depression and BC, highlighting a biological link underlying the observed phenotypic relationship; these findings may provide important implications for future studies aimed reducing BC risk.

Keyphrases

genome wide
depressive symptoms
sleep quality
copy number
genome wide association study
case control
young adults