Network connectivity alterations across the MAPT mutation clinical spectrum.
Liwen ZhangTaru M FlaganSuvi HäkkinenStephanie A ChuJesse A BrownAlex J LeeLorenzo PasquiniMaria Luisa MandelliMaria Luisa Gorno-TempiniVirginia E SturmJennifer S YokoyamaBrian S ApplebyYann CobigoBradford C DickersonKimiko Domoto-ReillyDaniel H GeschwindNupur GhoshalNeill R Graff-RadfordMurray GrossmanGing-Yuek Robin HsiungEdward D HueyKejal KantarciArgentina Lario LagoIrene LitvanIan R MackenzieMario F MendezChiadi U OnyikeEliana Marisa RamosErik D RobersonMaria Carmela TartagliaArthur W TogaSandra WeintraubZbigniew K WszolekLeah K ForsbergHilary W HeuerBradley F BoeveAdam L BoxerHoward J RosenBruce L MillerWilliam W SeeleySuzee E Leenull nullPublished in: Annals of neurology (2023)
Network connectivity alterations arise as early as the presymptomatic phase. Future studies will determine whether presymptomatic carriers' baseline connectivity profiles predict symptomatic conversion. This article is protected by copyright. All rights reserved.