Polygenic risk of high LDL cholesterol and ischemic heart disease in the general population.
Tim Møller EyrichNawar DalilaMette ChristoffersenAnne Tybjærg-HansenStefan Stender
Published in: Atherosclerosis (2024)
The top 1 % of LDL-PRS and CAD-PRS conferred effects on LDL-C and risk of IHD comparable to those seen for carriers of rare FH-causing variants in APOB or LDLR. These results highlight the potential value of implementing such PRS clinically.