Combined thermal ablation and liposomal granulocyte-macrophage colony stimulation factor increases immune cell trafficking in a small animal tumor model.
Marwan MoussaMd Raihan ChowdhuryDavid MwinMohamed FatihGokul SelverajAhmed AbdelmonemMohamed FarghalyQianhui DouNina FilipczakTatyana LevchenkoVladimir P TorchilinVassiliki BoussiotisS Nahum GoldbergMuneeb AhmedPublished in: PloS one (2023)
Systemic liposomal GM-CSF combined with RFA improves intratumoral immune cell trafficking, specifically populations initiating (DC, M1) and executing (CTL, FasL+) anti-tumor immunity. Moreover, liposomes influence synchronous untreated metastases increasing Th1, CTL and DCs infiltration.