C-C motif chemokine receptor 9 regulates obesity-induced insulin resistance via inflammation of the small intestine in mice.
Takeru AmiyaNobuhiro NakamotoJunichiro IrieNobuhito TanikiPo-Sung ChuYuzo KodaKentaro MiyamotoAkihiro YamaguchiShunsuke ShibaRei MorikawaHiroshi ItohTakanori KanaiPublished in: Diabetologia (2021)
CCR9 plays a central role in the pathogenesis of type 2 diabetes by inducing an inflammatory shift in the small intestine. Our findings support CCR9 as a new therapeutic target for type 2 diabetes via the gut-VAT-liver axis.
Keyphrases
- type diabetes
- insulin resistance
- high fat diet induced
- oxidative stress
- glycemic control
- metabolic syndrome
- high fat diet
- adipose tissue
- dendritic cells
- regulatory t cells
- diabetic rats
- skeletal muscle
- polycystic ovary syndrome
- high glucose
- cardiovascular disease
- drug induced
- weight loss
- endothelial cells
- body mass index
- stress induced
- binding protein