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Heterotypic macrophages/microglia differentially contribute to retinal ischaemia and neovascularisation.

Muneo YamaguchiShintaro NakaoMitsuru ArimaKaris LittleAditi SinghIori WadaYoshihiro KaizuSouska ZandiJustus G GarwegTetsuya MatobaWataru ShiraishiRyo YamasakiKensuke ShibataYasuhiro GoTatsuro IshibashiAkiyoshi UemuraAlan W StittKoh-Hei Sonoda
Published in: Diabetologia (2024)
These results collectively indicated that heterotypic macrophages/microglia differentially contribute to retinal ischaemia and neovascularisation in retinal vascular diseases including diabetic retinopathy. This adds important new information that could provide a basis for a more targeted, cell-specific therapeutic approach to prevent progression to sight-threatening PDR.
Keyphrases
  • diabetic retinopathy
  • optical coherence tomography
  • inflammatory response
  • neuropathic pain
  • single cell
  • cell therapy
  • healthcare
  • optic nerve
  • cancer therapy
  • stem cells
  • mesenchymal stem cells
  • bone marrow
  • drug delivery