Bioassay-Guided Isolation of Antiproliferative Compounds from Limbarda crithmoides (L.) Dumort.
Sabrina AdorisioLaura GiamperiAnahi Elena Ada BucchiniDomenico Vittorio DelfinoMaria Carla MarcotullioPublished in: Molecules (Basel, Switzerland) (2020)
Limbarda crithmoides (L.) Dumort (Asteraceae) n-hexane extract displayed high cell proliferation inhibitory activity against acute myeloid leukaemia cells (OCI-AML3) and was therefore subjected to a bioassay-guided multistep separation procedure. Two thymol derivatives, namely 10-acetoxy-8,9-epoxythymol tiglate (1) and 10-acetoxy-9-chloro-8,9-dehydrothymol (2), were isolated and identified by means of NMR spectroscopy. Both of them exhibited a significant dose-dependent inhibition of cell proliferation.
Keyphrases
- cell proliferation
- acute myeloid leukemia
- induced apoptosis
- cell cycle arrest
- cell cycle
- pi k akt
- liver failure
- oxidative stress
- dendritic cells
- bone marrow
- minimally invasive
- drug induced
- signaling pathway
- endoplasmic reticulum stress
- cell death
- aortic dissection
- intensive care unit
- mass spectrometry
- structure activity relationship
- mechanical ventilation