APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's disease.
Elles KonijnenbergBetty M TijmsJohan GobomValerija DobricicIsabelle BosStephanie VosMagda TsolakiFrans VerheyJulius PoppPablo Martinez-LageRik VandenbergheAlberto LleóLutz FrölichSimon LovestoneJohannes StrefferLars BertramKaj BlennowCharlotte E TeunissenRobert VeerhuisAugust B SmitPhilip ScheltensHenrik ZetterbergPieter Jelle VisserPublished in: Alzheimer's research & therapy (2020)
These results imply that AD pathophysiology depends on APOE genotype and that treatment for AD may need to be tailored according to APOE genotype and severity of the cognitive impairment.