Pharmacological modulation of the behavioral effects of social defeat in memory and learning in male mice.

M Carmen Blanco-GandiaSandra Montagud-RomeroJavier Navarro-ZaragozaElena Martínez-LaordenPilar AlmelaCristina NuñezMaria-Victoria MilanésMaría-Luisa LaordenJosé MiñarroMarta Rodríguez-Arias

Published in: Psychopharmacology (2019)

Our results demonstrate that the long-lasting effects of social defeat on anxiety and cognition are modulated by cocaine administration. Our results highlight that the BDNF signaling pathway could be a target to counteract the effects of cocaine on socially stressed subjects.

Keyphrases

signaling pathway
healthcare
mental health
pi k akt
working memory
epithelial mesenchymal transition
mild cognitive impairment
prefrontal cortex
white matter
sleep quality
endoplasmic reticulum stress