Dichloroacetate inhibits the degeneration of decellularized cardiovascular implants.

Agunda ChekhoevaSentaro NakanishiYukiharu SugimuraMahfuza ToshmatovaAnna Kathrin Assmann Artur Lichtenberg Payam Akhyari Anna Kathrin Assmann

Published in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021)

Systemic DCA treatment reduces adverse neointima hyperplasia in decellularized small-caliber arterial grafts, while allowing for rapid re-endothelialization. Furthermore, DCA inhibits calcification of the implants.

Keyphrases

extracellular matrix
soft tissue
chronic kidney disease
tissue engineering
emergency department
combination therapy
replacement therapy
drug induced