Platelet vesicles are potent inflammatory mediators in red blood cell products and washing reduces the inflammatory phenotype.
Ruqayyah J AlmizraqBetty J KipkeuJason P AckerPublished in: Transfusion (2019)
Platelet-EVs in RCCs are associated with pro-inflammatory activity. As washing significantly reduced RCC immunomodulatory activity, implementation of this process may improve transfusion outcomes.